483: Detlev Boison Discovers Why A Ketogenic Diet Controls Epilepsy And Low-Carb Physician Dr. Fred Pescatore


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Epilepsy researcher Detlev Boison and low-carb physician Dr. Fred Pescatore are our guests today on The Livin’ La Vida Low-Carb Show with Jimmy Moore!

Detlev Boison is the lead researcher on a study examining the underlying reasons why a ketogenic diet (high-fat, low-carb) is such an effective means of controlling epilepsy and the resulting seizures. Today he joins us for a quick last-minute interview we weren’t sure we’d get before today’s episode–but it’s cutting-edge stuff we know you’ll love and appreciate! Jimmy and Detlev discuss the new published study, its applicability to human physiology, protein pathology and so much more!

Then in the main interview today, Jimmy invites an old friend of his who’s never been on the podcast before–the great Dr. Fred Pescatore. Jimmy and Dr. Pescatore talk about his years at the Atkins Center working with the late Dr. Robert C. Atkins, the state of low-carb science in 2011, the denial of science by medical schools and many other timely topics! This is a fabulous episode you won’t want to miss!

Special thanks to our sponsor Yes! To Cookies.

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Detlev Boison bio
June 23, 2011 study published in The Journal of Clinical Investigation called “A ketogenic diet suppresses seizures in mice through adenosine A1 receptors”
– RELATED PODCAST: Dr. Eric Kossoff Treats Epilepsy With A ‘Modified Atkins’ Ketogenic Diet (Episode 367)
– RELATED PODCAST: Dr. Deborah Snyder On The Low-Carb Cure For Epilepsy (Episode 282)
Dr. Fred Pescatore bio
Official web site for Dr. Fred Pescatore
Gary Taubes’ “Is Sugar Toxic?” April 2011 column in The New York Times
Dr. Fred Pescatore on Twitter
Dr. Fred Pescatore on Facebook

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12 Responses to 483: Detlev Boison Discovers Why A Ketogenic Diet Controls Epilepsy And Low-Carb Physician Dr. Fred Pescatore
  1. Philis
    June 27, 2011 | 3:17 pm

    Hi. What do you think of the TurboCharge Diet? Dian & Tom Griesel. Apparently, Dr. Pescatore wrote a very positive forward in their book. Their approach is a little different. Just heard a podcast with Dian a couple days ago, and am curious but not wanting to buy the book if it does not really work for all/most people.


    • Jimmy Moore
      June 28, 2011 | 1:16 pm

      Never heard of it.

  2. Jill
    June 28, 2011 | 12:12 am

    Thank you for these interviews Jimmy. Macadamias are native to the subtropical rainforests of Australia’s east coast. It is the only plant food, native to Australia, that is produced and exported in any significant quantity. The nuts are a delicious, satisfying, nutritious snack. Please note, they are toxic to dogs.

    • Jimmy Moore
      June 28, 2011 | 12:09 pm

      Macadamia nuts are toxic to dogs? REALLY?! Did not know that. I knew Xylitol was, but had never heard of this. Interesting!

  3. Cindy
    June 28, 2011 | 5:28 pm

    I disagreed strongly with Dr. Pescatore’s big government solution to everything. Instead of switching our agricultural subsidies to different recipients, as he wanted, why not just end all subsidies? The problem with the government regulating how we eat is that the policies become entrenched in the government’s bureaucracy and thus are never subject to correction. That’s beyond the government’s proper role.

  4. Greg
    June 29, 2011 | 6:30 am

    Do you know if it was animal fat or vegetable oils that the mice were eating?

    • Jimmy Moore
      June 29, 2011 | 12:24 pm

      Don’t know for sure, Greg, but I’d highly doubt it was all vegetable oil. I can ask Detlev to respond. :)

      • Jimmy Moore
        June 30, 2011 | 7:27 pm

        Here’s his response:

        Regarding your question, here are the ingredients of the diet we used:

        Lard, Butter, Corn Oil, Casein, Cellulose, Mineral Mix, Vitamin Mix, Dextrose

        Thus, a mix of corn oil and animal-based fats.

        • Greg
          July 1, 2011 | 7:55 am

          Thank you for following up. I know that in a lot of animal studies the ‘low-carb’ diet is actually high in carbs and the fat consists of vegetable oils and hydrogenated oils, so it usually gets very poor results. This study actually worked so I was certain that animal fat would be in there. I’m sure that without the corn oil the results would be even more amazing.

  5. Vicky
    June 30, 2011 | 10:52 am

    I enjoyed the show especially the interview with Dr Pescatore. However He came off as little bit too judgmental in my opinion. I think will power is important in weight loss goals but clearly he has never been a fat person so he doesn’t understand the struggle. It irritates me when people turn this into a moral issue when it is mostly an educational one.

    Before will power plays ANY role in weight loss, people have to be given the correct information about diet and health. We as a nation have been lied to for decades by every known expert source out there about these issues so what does he expect? Those of us who are finally in the know are here because after years of struggling we had to seek this information out for ourselves. Millions of others are still ignorant and struggling out there and its up to us to help educate them, one family and member/friend at a time.

    • Vicky
      June 30, 2011 | 11:10 am

      Ok I’ll have to take some of that back. After listening all the way through he did say that he had to lose 80 pounds at one time (about what I have to lose). It’s just that the word “willpower” touches a nerve with me when the wrong information is being given at almost every turn.

      • Shannon
        July 3, 2011 | 10:39 am


        I was a bit offended as well. But then I realized that he is totally right. I had to sort of work through my feelings about why I was offended by what he said. Especially when he said that he is offended when he sees an overweight person eating ice cream. It sort of really hit a nerve with me. Then I realized that it is because I have self-doubt, wondering if I will ever be able to get to a healthy weight and avoid junk food. He is straight to the point. And, in retrospect, I do appreciate it. He is right, although the truth still stings a bit.

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